Synthetic and natural polycationic polymer nanoparticles interact selectively with fluid-phase domains of DMPC lipid bilayers

Almut Mecke; Dong Kuk Lee; Ayyalusamy Ramamoorthy; Bradford G. Orr; Mark M.Banaszak Holl

doi:10.1021/la051800w

Synthetic and natural polycationic polymer nanoparticles interact selectively with fluid-phase domains of DMPC lipid bilayers

Almut Mecke, Dong Kuk Lee, Ayyalusamy Ramamoorthy, Bradford G. Orr, Mark M.Banaszak Holl

Dept. of Fine Chemistry

University of Michigan, Ann Arbor

Research output: Contribution to journal › Article › peer-review

131 Scopus citations

Abstract

Polycationic polymers are known to disrupt lipid bilayers. In this letter, we report the dependence of this disruption on the lipid structural phase. DMPC bilayers are exposed to two polycationic polymeric nanoparticles, PAMAM dendrimers and MSI-78. We find that regions of the bilayer that are in the gel phase are unaffected by the presence of polymers, whereas the liquid phase is disrupted.

Original language	English
Pages (from-to)	8588-8590
Number of pages	3
Journal	Langmuir
Volume	21
Issue number	19
DOIs	https://doi.org/10.1021/la051800w
State	Published - 13 Sep 2005

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abstract = "Polycationic polymers are known to disrupt lipid bilayers. In this letter, we report the dependence of this disruption on the lipid structural phase. DMPC bilayers are exposed to two polycationic polymeric nanoparticles, PAMAM dendrimers and MSI-78. We find that regions of the bilayer that are in the gel phase are unaffected by the presence of polymers, whereas the liquid phase is disrupted.",

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AU - Lee, Dong Kuk

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AU - Orr, Bradford G.

AU - Holl, Mark M.Banaszak

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N2 - Polycationic polymers are known to disrupt lipid bilayers. In this letter, we report the dependence of this disruption on the lipid structural phase. DMPC bilayers are exposed to two polycationic polymeric nanoparticles, PAMAM dendrimers and MSI-78. We find that regions of the bilayer that are in the gel phase are unaffected by the presence of polymers, whereas the liquid phase is disrupted.

AB - Polycationic polymers are known to disrupt lipid bilayers. In this letter, we report the dependence of this disruption on the lipid structural phase. DMPC bilayers are exposed to two polycationic polymeric nanoparticles, PAMAM dendrimers and MSI-78. We find that regions of the bilayer that are in the gel phase are unaffected by the presence of polymers, whereas the liquid phase is disrupted.

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Synthetic and natural polycationic polymer nanoparticles interact selectively with fluid-phase domains of DMPC lipid bilayers

Abstract

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