Three-Dimensional Tungsten Disulfide Raman Biosensor for Dopamine Detection

Noho Lee; Myeong Hwan Shin; Eunho Lee; Seong Hui Cho; Hyeonwoong Hwang; Kilwon Cho; Jong Kyu Kim; Sei Kwang Hahn

doi:10.1021/acsabm.0c00876

Three-Dimensional Tungsten Disulfide Raman Biosensor for Dopamine Detection

Noho Lee, Myeong Hwan Shin, Eunho Lee, Seong Hui Cho, Hyeonwoong Hwang, Kilwon Cho, Jong Kyu Kim, Sei Kwang Hahn

Dept. of Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Two-dimensional (2D) transition metal dichalcogenides (TMDCs) are promising materials for detection of biomolecules due to their large surface-to-volume ratio. However, their poor response to the cellular environment hinders the realization of high-performance 2D TMDC sensors. Here, we present a hierarchical Raman scattering sensor consisting of the WS2 directly grown on an array of three-dimensional (3D) WO3 nanohelixes (NHs) by sulfurization. Both the adsorption of biomolecules and the proliferation of cells are significantly promoted for the 3D WS2/WO3 NH sensor compared to the control sensor with sulfurized WS2 on 2D WO3 film, leading to much enhanced sensitivity to dopamine. In addition, according to the in vitro test using PC12 cells, the 3D WS2/WO3 NH sensor shows a significant increase in hydrophobicity and Raman frequency shift, indicating that both the attachment of cells and the detection of biomolecules are improved.

Original language	English
Pages (from-to)	7687-7695
Number of pages	9
Journal	ACS Applied Bio Materials
Volume	3
Issue number	11
DOIs	https://doi.org/10.1021/acsabm.0c00876
State	Published - 16 Nov 2020

Keywords

3D nanostructure
biomolecule detection
cytocompatibility
Raman frequency shift
tungsten disulfide

Access to Document

10.1021/acsabm.0c00876

Cite this

@article{f45c1d084ff945d48dcf80f2eb09fd9a,

title = "Three-Dimensional Tungsten Disulfide Raman Biosensor for Dopamine Detection",

abstract = "Two-dimensional (2D) transition metal dichalcogenides (TMDCs) are promising materials for detection of biomolecules due to their large surface-to-volume ratio. However, their poor response to the cellular environment hinders the realization of high-performance 2D TMDC sensors. Here, we present a hierarchical Raman scattering sensor consisting of the WS2 directly grown on an array of three-dimensional (3D) WO3 nanohelixes (NHs) by sulfurization. Both the adsorption of biomolecules and the proliferation of cells are significantly promoted for the 3D WS2/WO3 NH sensor compared to the control sensor with sulfurized WS2 on 2D WO3 film, leading to much enhanced sensitivity to dopamine. In addition, according to the in vitro test using PC12 cells, the 3D WS2/WO3 NH sensor shows a significant increase in hydrophobicity and Raman frequency shift, indicating that both the attachment of cells and the detection of biomolecules are improved.",

keywords = "3D nanostructure, biomolecule detection, cytocompatibility, Raman frequency shift, tungsten disulfide",

author = "Noho Lee and Shin, \{Myeong Hwan\} and Eunho Lee and Cho, \{Seong Hui\} and Hyeonwoong Hwang and Kilwon Cho and Kim, \{Jong Kyu\} and Hahn, \{Sei Kwang\}",

note = "Publisher Copyright: {\textcopyright} ",

year = "2020",

month = nov,

day = "16",

doi = "10.1021/acsabm.0c00876",

language = "English",

volume = "3",

pages = "7687--7695",

journal = "ACS Applied Bio Materials",

issn = "2576-6422",

number = "11",

}

TY - JOUR

T1 - Three-Dimensional Tungsten Disulfide Raman Biosensor for Dopamine Detection

AU - Lee, Noho

AU - Shin, Myeong Hwan

AU - Lee, Eunho

AU - Cho, Seong Hui

AU - Hwang, Hyeonwoong

AU - Cho, Kilwon

AU - Kim, Jong Kyu

AU - Hahn, Sei Kwang

N1 - Publisher Copyright: ©

PY - 2020/11/16

Y1 - 2020/11/16

N2 - Two-dimensional (2D) transition metal dichalcogenides (TMDCs) are promising materials for detection of biomolecules due to their large surface-to-volume ratio. However, their poor response to the cellular environment hinders the realization of high-performance 2D TMDC sensors. Here, we present a hierarchical Raman scattering sensor consisting of the WS2 directly grown on an array of three-dimensional (3D) WO3 nanohelixes (NHs) by sulfurization. Both the adsorption of biomolecules and the proliferation of cells are significantly promoted for the 3D WS2/WO3 NH sensor compared to the control sensor with sulfurized WS2 on 2D WO3 film, leading to much enhanced sensitivity to dopamine. In addition, according to the in vitro test using PC12 cells, the 3D WS2/WO3 NH sensor shows a significant increase in hydrophobicity and Raman frequency shift, indicating that both the attachment of cells and the detection of biomolecules are improved.

AB - Two-dimensional (2D) transition metal dichalcogenides (TMDCs) are promising materials for detection of biomolecules due to their large surface-to-volume ratio. However, their poor response to the cellular environment hinders the realization of high-performance 2D TMDC sensors. Here, we present a hierarchical Raman scattering sensor consisting of the WS2 directly grown on an array of three-dimensional (3D) WO3 nanohelixes (NHs) by sulfurization. Both the adsorption of biomolecules and the proliferation of cells are significantly promoted for the 3D WS2/WO3 NH sensor compared to the control sensor with sulfurized WS2 on 2D WO3 film, leading to much enhanced sensitivity to dopamine. In addition, according to the in vitro test using PC12 cells, the 3D WS2/WO3 NH sensor shows a significant increase in hydrophobicity and Raman frequency shift, indicating that both the attachment of cells and the detection of biomolecules are improved.

KW - 3D nanostructure

KW - biomolecule detection

KW - cytocompatibility

KW - Raman frequency shift

KW - tungsten disulfide

UR - http://www.scopus.com/inward/record.url?scp=85097078266&partnerID=8YFLogxK

U2 - 10.1021/acsabm.0c00876

DO - 10.1021/acsabm.0c00876

M3 - Article

AN - SCOPUS:85097078266

SN - 2576-6422

VL - 3

SP - 7687

EP - 7695

JO - ACS Applied Bio Materials

JF - ACS Applied Bio Materials

IS - 11

ER -

Three-Dimensional Tungsten Disulfide Raman Biosensor for Dopamine Detection

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this