Validation of a model of regulation in the tryptophan operon against multiple experiment data using global optimisation

Jongrae Kim, Jung Su Kim, Ian Postlethwaite, Pat Heslop-Harrison, Declan G. Bates

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

This paper is concerned with validating a mathematical model of regulation in the tryptophan operon using global optimization. Although a number of models for this biochemical network are proposed, in many cases only qualitative agreement between the model output and experimental data was demonstrated, since very little information is currently available to guide the selection of parameter values for the models. This paper presents a model validating method using both multiple experimental data and global optimization.

Original languageEnglish
Title of host publicationICCAS-SICE 2009 - ICROS-SICE International Joint Conference 2009, Proceedings
Pages209-211
Number of pages3
StatePublished - 2009
EventICROS-SICE International Joint Conference 2009, ICCAS-SICE 2009 - Fukuoka, Japan
Duration: 18 Aug 200921 Aug 2009

Publication series

NameICCAS-SICE 2009 - ICROS-SICE International Joint Conference 2009, Proceedings

Conference

ConferenceICROS-SICE International Joint Conference 2009, ICCAS-SICE 2009
Country/TerritoryJapan
CityFukuoka
Period18/08/0921/08/09

Keywords

  • Global optimization
  • Model validation
  • Parameter identification
  • Tryptophan regulation

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