Whole cell impedance analysis of metastatic and non-metastatic cancer cells

H. S. Kim; Y. H. Cho; A. B. Frazier; Z. Chen; D. M. Shin; A. Han

doi:10.1109/MEMSYS.2009.4805403

Whole cell impedance analysis of metastatic and non-metastatic cancer cells

H. S. Kim, Y. H. Cho, A. B. Frazier, Z. Chen, D. M. Shin, A. Han

Dept. of Mechanical System and Design Engineering

Research output: Contribution to journal › Conference article › peer-review

Abstract

We have developed a micro electrical impedance spectroscopy (μEIS) system and utilized it for analyzing highly-metastatic and poorly-metastatic head and neck cancer (HNC) cell lines. The device is composed of 16 arrays of impedance analysis sites, with each site capable of capturing a single cell and analyzing its electrical impedance spectrum. Electrical impedance measurements on the highly-metastatic HNC cell line 686LN-M4e and the poorly-metastatic HNC cell line 686LN were conducted over a frequency range of 40 Hz to 10 MHz. The phase part of the impedance spectrums from the 686LN-M4e and 686LN cells showed clear difference. This result indicates that the μEIS system can be used to distinguish the metastatic status of HNC cell lines.

Original language	English
Article number	4805403
Pages (from-to)	399-402
Number of pages	4
Journal	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
DOIs	https://doi.org/10.1109/MEMSYS.2009.4805403
State	Published - 2009
Event	22nd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2009 - Sorrento, Italy Duration: 25 Jan 2009 → 29 Jan 2009

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10.1109/MEMSYS.2009.4805403

Cite this

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title = "Whole cell impedance analysis of metastatic and non-metastatic cancer cells",

abstract = "We have developed a micro electrical impedance spectroscopy (μEIS) system and utilized it for analyzing highly-metastatic and poorly-metastatic head and neck cancer (HNC) cell lines. The device is composed of 16 arrays of impedance analysis sites, with each site capable of capturing a single cell and analyzing its electrical impedance spectrum. Electrical impedance measurements on the highly-metastatic HNC cell line 686LN-M4e and the poorly-metastatic HNC cell line 686LN were conducted over a frequency range of 40 Hz to 10 MHz. The phase part of the impedance spectrums from the 686LN-M4e and 686LN cells showed clear difference. This result indicates that the μEIS system can be used to distinguish the metastatic status of HNC cell lines.",

author = "Kim, \{H. S.\} and Cho, \{Y. H.\} and Frazier, \{A. B.\} and Z. Chen and Shin, \{D. M.\} and A. Han",

year = "2009",

doi = "10.1109/MEMSYS.2009.4805403",

language = "English",

pages = "399--402",

journal = "Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)",

issn = "1084-6999",

note = "22nd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2009 ; Conference date: 25-01-2009 Through 29-01-2009",

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TY - JOUR

T1 - Whole cell impedance analysis of metastatic and non-metastatic cancer cells

AU - Kim, H. S.

AU - Cho, Y. H.

AU - Frazier, A. B.

AU - Chen, Z.

AU - Shin, D. M.

AU - Han, A.

PY - 2009

Y1 - 2009

N2 - We have developed a micro electrical impedance spectroscopy (μEIS) system and utilized it for analyzing highly-metastatic and poorly-metastatic head and neck cancer (HNC) cell lines. The device is composed of 16 arrays of impedance analysis sites, with each site capable of capturing a single cell and analyzing its electrical impedance spectrum. Electrical impedance measurements on the highly-metastatic HNC cell line 686LN-M4e and the poorly-metastatic HNC cell line 686LN were conducted over a frequency range of 40 Hz to 10 MHz. The phase part of the impedance spectrums from the 686LN-M4e and 686LN cells showed clear difference. This result indicates that the μEIS system can be used to distinguish the metastatic status of HNC cell lines.

AB - We have developed a micro electrical impedance spectroscopy (μEIS) system and utilized it for analyzing highly-metastatic and poorly-metastatic head and neck cancer (HNC) cell lines. The device is composed of 16 arrays of impedance analysis sites, with each site capable of capturing a single cell and analyzing its electrical impedance spectrum. Electrical impedance measurements on the highly-metastatic HNC cell line 686LN-M4e and the poorly-metastatic HNC cell line 686LN were conducted over a frequency range of 40 Hz to 10 MHz. The phase part of the impedance spectrums from the 686LN-M4e and 686LN cells showed clear difference. This result indicates that the μEIS system can be used to distinguish the metastatic status of HNC cell lines.

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DO - 10.1109/MEMSYS.2009.4805403

M3 - Conference article

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SN - 1084-6999

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EP - 402

JO - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)

JF - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)

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T2 - 22nd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2009

Y2 - 25 January 2009 through 29 January 2009

ER -

Whole cell impedance analysis of metastatic and non-metastatic cancer cells

Abstract

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