Yeast metabolic engineering for carbon dioxide fixation and its application

Soo Rin Kim; Soo Jung Kim; Sun Ki Kim; Seung Oh Seo; Sujeong Park; Jamin Shin; Jeong Sun Kim; Bo Ram Park; Yong Su Jin; Pahn Shick Chang; Yong Cheol Park

doi:10.1016/j.biortech.2021.126349

Yeast metabolic engineering for carbon dioxide fixation and its application

Soo Rin Kim
, Soo Jung Kim
, Sun Ki Kim
, Seung Oh Seo
, Sujeong Park
, Jamin Shin
, Jeong Sun Kim
, Bo Ram Park
, Yong Su Jin
, Pahn Shick Chang
, Yong Cheol Park

Dept. of Food Science and Technology

Kyungpook National University
Chonnam National University
Chung-Ang University
Rural Development Administration
University of Illinois at Urbana-Champaign
Seoul National University
Kookmin University

Research output: Contribution to journal › Review article › peer-review

31 Scopus citations

Abstract

As numerous industrial bioprocesses rely on yeast fermentation, developing CO₂-fixing yeast strains can be an attractive option toward sustainable industrial processes and carbon neutrality. Recent studies have shown that the expression of ribulose-1,5-bisphosphate carboxylase-oxygenase (RuBisCO) in yeasts, such as Saccharomyces cerevisiae and Kluyveromyces marxianus, enables mixotrophic CO₂ fixation and production of biofuels. Also, the expression of a synthetic Calvin-Benson-Bassham (CBB) cycle including RuBisCO in Pichia pastoris enables autotrophic growth on CO₂. This review highlights recent advances in metabolic engineering strategies to enable CO₂ fixation in yeasts. Also, we discuss the potentials of other natural and synthetic metabolic pathways independent of RuBisCO for developing CO₂-fixing yeast strains capable of producing value-added biochemicals.

Original language	English
Article number	126349
Journal	Bioresource Technology
Volume	346
DOIs	https://doi.org/10.1016/j.biortech.2021.126349
State	Published - Feb 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 7 Affordable and Clean Energy
SDG 9 Industry, Innovation, and Infrastructure

Keywords

Calvin-Benson-Bassham (CBB) cycle
Carbon dioxide fixation
Ribulose-1,5-bisphosphate carboxylase-oxygenase (RuBisCO)
Yeast metabolic engineering

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10.1016/j.biortech.2021.126349

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@article{fdd1d18f7cde49d4990cadf0648043c4,

title = "Yeast metabolic engineering for carbon dioxide fixation and its application",

abstract = "As numerous industrial bioprocesses rely on yeast fermentation, developing CO2-fixing yeast strains can be an attractive option toward sustainable industrial processes and carbon neutrality. Recent studies have shown that the expression of ribulose-1,5-bisphosphate carboxylase-oxygenase (RuBisCO) in yeasts, such as Saccharomyces cerevisiae and Kluyveromyces marxianus, enables mixotrophic CO2 fixation and production of biofuels. Also, the expression of a synthetic Calvin-Benson-Bassham (CBB) cycle including RuBisCO in Pichia pastoris enables autotrophic growth on CO2. This review highlights recent advances in metabolic engineering strategies to enable CO2 fixation in yeasts. Also, we discuss the potentials of other natural and synthetic metabolic pathways independent of RuBisCO for developing CO2-fixing yeast strains capable of producing value-added biochemicals.",

keywords = "Calvin-Benson-Bassham (CBB) cycle, Carbon dioxide fixation, Ribulose-1,5-bisphosphate carboxylase-oxygenase (RuBisCO), Yeast metabolic engineering",

author = "\{Rin Kim\}, Soo and Kim, \{Soo Jung\} and Kim, \{Sun Ki\} and Seo, \{Seung Oh\} and Sujeong Park and Jamin Shin and Kim, \{Jeong Sun\} and Park, \{Bo Ram\} and Jin, \{Yong Su\} and Chang, \{Pahn Shick\} and Park, \{Yong Cheol\}",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2022",

month = feb,

doi = "10.1016/j.biortech.2021.126349",

language = "English",

volume = "346",

journal = "Bioresource Technology",

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TY - JOUR

T1 - Yeast metabolic engineering for carbon dioxide fixation and its application

AU - Rin Kim, Soo

AU - Kim, Soo Jung

AU - Kim, Sun Ki

AU - Seo, Seung Oh

AU - Park, Sujeong

AU - Shin, Jamin

AU - Kim, Jeong Sun

AU - Park, Bo Ram

AU - Jin, Yong Su

AU - Chang, Pahn Shick

AU - Park, Yong Cheol

PY - 2022/2

Y1 - 2022/2

N2 - As numerous industrial bioprocesses rely on yeast fermentation, developing CO2-fixing yeast strains can be an attractive option toward sustainable industrial processes and carbon neutrality. Recent studies have shown that the expression of ribulose-1,5-bisphosphate carboxylase-oxygenase (RuBisCO) in yeasts, such as Saccharomyces cerevisiae and Kluyveromyces marxianus, enables mixotrophic CO2 fixation and production of biofuels. Also, the expression of a synthetic Calvin-Benson-Bassham (CBB) cycle including RuBisCO in Pichia pastoris enables autotrophic growth on CO2. This review highlights recent advances in metabolic engineering strategies to enable CO2 fixation in yeasts. Also, we discuss the potentials of other natural and synthetic metabolic pathways independent of RuBisCO for developing CO2-fixing yeast strains capable of producing value-added biochemicals.

AB - As numerous industrial bioprocesses rely on yeast fermentation, developing CO2-fixing yeast strains can be an attractive option toward sustainable industrial processes and carbon neutrality. Recent studies have shown that the expression of ribulose-1,5-bisphosphate carboxylase-oxygenase (RuBisCO) in yeasts, such as Saccharomyces cerevisiae and Kluyveromyces marxianus, enables mixotrophic CO2 fixation and production of biofuels. Also, the expression of a synthetic Calvin-Benson-Bassham (CBB) cycle including RuBisCO in Pichia pastoris enables autotrophic growth on CO2. This review highlights recent advances in metabolic engineering strategies to enable CO2 fixation in yeasts. Also, we discuss the potentials of other natural and synthetic metabolic pathways independent of RuBisCO for developing CO2-fixing yeast strains capable of producing value-added biochemicals.

KW - Calvin-Benson-Bassham (CBB) cycle

KW - Carbon dioxide fixation

KW - Ribulose-1,5-bisphosphate carboxylase-oxygenase (RuBisCO)

KW - Yeast metabolic engineering

UR - https://www.scopus.com/pages/publications/85119487059

U2 - 10.1016/j.biortech.2021.126349

DO - 10.1016/j.biortech.2021.126349

M3 - Review article

C2 - 34800639

AN - SCOPUS:85119487059

SN - 0960-8524

VL - 346

JO - Bioresource Technology

JF - Bioresource Technology

M1 - 126349

ER -

Yeast metabolic engineering for carbon dioxide fixation and its application

Abstract

UN SDGs

Keywords

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